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The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning. In the outer epidermis, their consecutive actions oxidize linoleic acid esterified in ω-hydroxy-ceramide to a hepox...

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Autores principales: Muñoz-Garcia, Agustí, Thomas, Christopher P., Keeney, Diane S., Zheng, Yuxiang, Brash, Alan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116325/
https://ncbi.nlm.nih.gov/pubmed/24021977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2013.08.020
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