Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 also regulates gluconeogenesis is less clear. Here, we report that p53 efficiently down-regulates the expression of phosp...

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Bibliografiske detaljer
Main Authors: Zhang, Ping, Tu, Bo, Wang, Hua, Cao, Ziyang, Tang, Ming, Zhang, Chaohua, Gu, Bo, Li, Zhiming, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Haiying, Luo, Jianyuan, Deng, Chu-Xia, Gao, Bin, Roeder, Robert G., Zhu, Wei-Guo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115576/
https://ncbi.nlm.nih.gov/pubmed/25009184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411026111
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