Differences in mutagenicity and cytotoxicity of (+)- and (-)-benzo[a]pyrene 4,5-oxide: a synergistic interaction of enantiomers.

In order to study the biological effects of (+)- and (-)-benzo[a]pyrene 4,5-oxide, a synthesis of these molecules has been developed based on the resolution of (+/-)-cis-4,5-dihydroxy-4,5-dihydrobenzo[a]pyrene. The (-) enantiomer of benzo[a]pyrene 4,5-oxide was 1.5- to 5.5-fold more mutagenic than t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chang, R L, Wood, A W, Levin, W, Mah, H D, Thakker, D R, Jerina, D M, Conney, A H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1979
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/388437/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.9.4280
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