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Differences in mutagenicity and cytotoxicity of (+)- and (-)-benzo[a]pyrene 4,5-oxide: a synergistic interaction of enantiomers.

In order to study the biological effects of (+)- and (-)-benzo[a]pyrene 4,5-oxide, a synthesis of these molecules has been developed based on the resolution of (+/-)-cis-4,5-dihydroxy-4,5-dihydrobenzo[a]pyrene. The (-) enantiomer of benzo[a]pyrene 4,5-oxide was 1.5- to 5.5-fold more mutagenic than t...

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Detalles Bibliográficos
Main Authors: Chang, R L, Wood, A W, Levin, W, Mah, H D, Thakker, D R, Jerina, D M, Conney, A H
Formato: Artigo
Idioma:Inglês
Publicado: 1979
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC411557/
https://ncbi.nlm.nih.gov/pubmed/388437
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