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Modulation of frustration in folding by sequence permutation
Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rough with local minima trapping frustrated species. These substructures impede productive folding and can serve as nucleation sites for aggregation reaction...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115504/ https://ncbi.nlm.nih.gov/pubmed/25002512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324230111 |
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