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Modulation of frustration in folding by sequence permutation
Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rough with local minima trapping frustrated species. These substructures impede productive folding and can serve as nucleation sites for aggregation reaction...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115504/ https://ncbi.nlm.nih.gov/pubmed/25002512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324230111 |
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