Increased activity of p53 in senescing fibroblasts.
The p53 tumor-suppressor protein binds DNA and activates the expression of a 21-kDa protein that inhibits both the activity of cyclin-dependent kinases and the function of proliferating cell nuclear antigen. Since p21 expression has been reported to increase 10- to 20-fold as human diploid fibroblas...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41154/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667293/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8348 |
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