Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones

A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)-based steroidomimetic microtubule disruptors has been extended to dihydroisoquinolinone (DHIQ)-based compounds. A steroid A,B-ring-mimicking DHIQ core was connected to methoxyaryl D-ring mimics through methylene,...

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Auteurs principaux: Leese, Mathew P, Jourdan, Fabrice L, Major, Meriel R, Dohle, Wolfgang, Thomas, Mark P, Hamel, Ernest, Ferrandis, Eric, Mahon, Mary F, Newman, Simon P, Purohit, Atul, Potter, Barry V L
Format: Artigo
Langue:Inglês
Publié: WILEY-VCH Verlag 2014
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Full Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114533/
https://ncbi.nlm.nih.gov/pubmed/24596315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201400017
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