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Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells

OBJECTIVE: The phenotypic modulation of vascular smooth muscle cells (VSMCs) to a synthetic phenotype is vital during pathological vascular remodeling and the development of various vascular diseases. An increase in type I collagen (collagen I) has been implicated in synthetic VSMCs, and cyclic nucl...

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Autori principali: Cai, Yujun, Miller, Clint L., Nagel, David J., Jeon, Kye-Im, Lim, Soyeon, Gao, Pingjin, Knight, Peter A., Yan, Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114343/
https://ncbi.nlm.nih.gov/pubmed/21148428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.212621
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