Role of Ca(2+)/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

RATIONALE: Cyclic nucleotide phosphodiesterases (PDE) through the degradation of second messenger cyclic guanosine monophosphate (cGMP) play critical roles in maintaining cardiomyocyte homeostasis. Ca(2+)/CaM-activated cGMP-hydrolyzing PDE1 family may play a pivotal role in balancing intracellular C...

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Detalhes bibliográficos
Main Authors: Miller, Clint L., Oikawa, Masayoshi, Cai, Yujun, Wojtovich, Andrew P., Nagel, David J., Xu, Xiangbin, Xu, Haodong, Florio, Vince, Rybalkin, Sergei D., Beavo, Joseph A., Chen, Yiu-Fai, Li, Jian-Dong, Blaxall, Burns C., Abe, Jun-ichi, Yan, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803071/
https://ncbi.nlm.nih.gov/pubmed/19797176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.198515
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