Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

The loss of synapses is a strong histological correlate of the cognitive decline in Alzheimer's disease (AD). Amyloid β−peptide (Aβ), a cleavage product of the amyloid precursor protein (APP), exerts detrimental effects on synapses, a process thought to be causally related to the cognitive defi...

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Autors principals: Liebscher, S, Page, R M, Käfer, K, Winkler, E, Quinn, K, Goldbach, E, Brigham, E F, Quincy, D, Basi, G S, Schenk, D B, Steiner, H, Bonhoeffer, T, Haass, C, Meyer-Luehmann, M, Hübener, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113951/
https://ncbi.nlm.nih.gov/pubmed/24061497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.122
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