MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microbial metabolites presented by the nonpolymorphic major histocompatibility complex (MHC)–like molecule MR1. The highly conserved nature of MR1 in conjunction with biased MAIT TCRα chain usage...

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Detalhes bibliográficos
Main Authors: Gold, Marielle C., McLaren, James E., Reistetter, Joseph A., Smyk-Pearson, Sue, Ladell, Kristin, Swarbrick, Gwendolyn M., Yu, Yik Y.L., Hansen, Ted H., Lund, Ole, Nielsen, Morten, Gerritsen, Bram, Kesmir, Can, Miles, John J., Lewinsohn, Deborah A., Price, David A., Lewinsohn, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113934/
https://ncbi.nlm.nih.gov/pubmed/25049333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140507
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