Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

Protein in vitro inhibition of thymidylate synthase (5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) by 5-fluoro-2'-deoxyuridylate requires 5,10-methylenetetrahydrofolate. The cytoxicity of 5-fluoro-2'-deoxyuridine towards cultured L1210 mouse leukemia cells is reduce...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ullman, B, Lee, M, Martin, D W, Santi, D V
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1978
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC411383/
https://ncbi.nlm.nih.gov/pubmed/147465
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