The Combined Repetitive Oligopeptides of Clostridium difficile Toxin A Counteract Premature Cleavage of the Glucosyl-Transferase Domain by Stabilizing Protein Conformation

Toxin A (TcdA) and B (TcdB) from Clostridium difficile enter host cells by receptor-mediated endocytosis. A prerequisite for proper toxin action is the intracellular release of the glucosyltransferase domain by an inherent cysteine protease, which is allosterically activated by inositol hexaphosphat...

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Main Authors: Olling, Alexandra, Hüls, Corinna, Goy, Sebastian, Müller, Mirco, Krooss, Simon, Rudolf, Isa, Tatge, Helma, Gerhard, Ralf
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113749/
https://ncbi.nlm.nih.gov/pubmed/25054784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins6072162
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