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Application of Mutated Clostridium difficile Toxin A for Determination of Glucosyltransferase-Dependent Effects
Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects wi...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1594915/ https://ncbi.nlm.nih.gov/pubmed/16988280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00545-06 |
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