Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

BACKGROUND: Long-lasting and sterile protective immunity against Plasmodium falciparum can be achieved by immunization of malaria-naive human volunteers under chloroquine prophylaxis with sporozoites delivered by mosquito bites (CPS-immunization). Protection is mediated by sporozoite/liver-stage imm...

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Main Authors: Behet, Marije C, Foquet, Lander, van Gemert, Geert-Jan, Bijker, Else M, Meuleman, Philip, Leroux-Roels, Geert, Hermsen, Cornelus C, Scholzen, Anja, Sauerwein, Robert W
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113136/
https://ncbi.nlm.nih.gov/pubmed/24708526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-136
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