Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia

Pseudomonas aeruginosa (PA) forms biofilms in lungs of cystic fibrosis CF) patients, a process regulated by quorum sensing molecules including N-(3-oxododecanoyl)-L-homoserine lactone, C12. C12 (10–100 μM) rapidly triggered events commonly associated with the intrinsic apoptotic pathway in JME (CFΔF...

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Main Authors: Schwarzer, Christian, Fu, Zhu, Patanwala, Maria, Hum, Lauren, Lopez-Guzman, Mirielle, Illek, Beate, Kong, Weidong, Lynch, Susan V., Machen, Terry E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112999/
https://ncbi.nlm.nih.gov/pubmed/22233488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2012.01753.x
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