TLR2 engagement on CD4(+)T cells enhances effector functions and protective responses to Mycobacterium tuberculosis

We have previously demonstrated that mycobacterial lipoproteins engage TLR2 on human CD4(+) T cells and up-regulate TCR triggered- IFN-γ secretion and cell proliferation in vitro. Here we examined the role of CD4(+) T cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T cell priming...

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Main Authors: Reba, Scott M, Li, Qing, Onwuzulike, Sophia, Ding, Xuedong, Karim, Ahmad F, Hernandez, Yeritza, Fulton, Scott A, Harding, Clifford V, Lancioni, Christina L, Nagy, Nancy, Rodriguez, Myriam E, Wearsch, Pamela A, Rojas, Roxana E
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112943/
https://ncbi.nlm.nih.gov/pubmed/24497180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344100
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