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Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication

BACKGROUND: The influenza A virus NS1 protein is a virulence factor and an antagonist of host cell innate immune responses. During virus infection NS1 protein has several functions both in the nucleus and in the cytoplasm and its intracellular localization is regulated by one or two nuclear localiza...

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Detalhes bibliográficos
Main Authors: Tynell, Janne, Melén, Krister, Julkunen, Ilkka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112715/
https://ncbi.nlm.nih.gov/pubmed/25023993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-11-128
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