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Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

BACKGROUND: Influenza A virus non-structural protein 1 (NS1) is a virulence factor, which is targeted into the cell cytoplasm, nucleus and nucleolus. NS1 is a multi-functional protein that inhibits host cell pre-mRNA processing and counteracts host cell antiviral responses. Previously, we have shown...

詳細記述

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書誌詳細
主要な著者: Melén, Krister, Tynell, Janne, Fagerlund, Riku, Roussel, Pascal, Hernandez-Verdun, Danièle, Julkunen, Ilkka
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493336/
https://ncbi.nlm.nih.gov/pubmed/22909121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-167
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