Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II

Glutamate carboxypeptidase II (GCPII) is an important target for therapeutic and diagnostic interventions aimed at prostate cancer and neurologic disorders. Here we describe the development and optimization of a high-throughput screening (HTS) assay based on fluorescence polarization (FP) that facil...

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Main Authors: Alquicer, Glenda, Sedlák, David, Byun, Youngjoo, Pavlíček, Jiří, Stathis, Marigo, Rojas, Camilo, Slusher, Barbara, Pomper, Martin G., Bartůněk, Petr, Bařinka, Cyril
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112551/
https://ncbi.nlm.nih.gov/pubmed/22751730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112451924
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