Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II

Glutamate carboxypeptidase II (GCPII) is an important target for therapeutic and diagnostic interventions aimed at prostate cancer and neurologic disorders. Here we describe the development and optimization of a high-throughput screening (HTS) assay based on fluorescence polarization (FP) that facil...

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Autori principali: Alquicer, Glenda, Sedlák, David, Byun, Youngjoo, Pavlíček, Jiří, Stathis, Marigo, Rojas, Camilo, Slusher, Barbara, Pomper, Martin G., Bartůněk, Petr, Bařinka, Cyril
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112551/
https://ncbi.nlm.nih.gov/pubmed/22751730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112451924
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