High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families

BACKGROUND: Germline mutations in the tumour suppressor gene CDKN2A occur in 5–20% of familial melanoma cases. A single founder mutation, p.Arg112dup, accounts for the majority of CDKN2A mutations in Swedish carriers. In a national program, carriers of p.Arg112dup mutation have been identified. The...

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Bibliografiska uppgifter
Huvudupphovsmän: Helgadottir, Hildur, Höiom, Veronica, Jönsson, Göran, Tuominen, Rainer, Ingvar, Christian, Borg, Åke, Olsson, Håkan, Hansson, Johan
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMJ Publishing Group 2014
Ämnen:
Cancer Genetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112445/
https://ncbi.nlm.nih.gov/pubmed/24935963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2014-102320
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