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Characterisation of the Clinical Pharmacokinetics of Actinomycin D and the Influence of ABCB1 Pharmacogenetic Variation on Actinomycin D Disposition in Children with Cancer

BACKGROUND AND OBJECTIVE: Despite its important role in cancer treatment, there is currently very limited available information concerning the clinical pharmacology of actinomycin D (Act D). The study was designed to characterise Act D pharmacokinetics and investigate the impact of pharmacogenetic v...

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Bibliografski detalji
Glavni autori: Hill, Christopher R., Cole, Michael, Errington, Julie, Malik, Ghada, Boddy, Alan V., Veal, Gareth J.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111883/
https://ncbi.nlm.nih.gov/pubmed/24968986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0153-2
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