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Phosphorylation of Akt at the C-terminal tail triggers Akt Activation
Aberrant hyper-activation of the protein kinase Akt plays a critical role in promoting tumorigenesis. Mechanistically, previous studies establish that phosphorylation of Akt at S473 and T308 by mTORC2 and PDK1, respectively, is necessary for its full activation, thereby having been used as Akt activ...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111671/ https://ncbi.nlm.nih.gov/pubmed/24933731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29584 |
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