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Synthesis of the novel (±)-2-methoxy-6-icosynoic acid – a fatty acid that induces death of neuroblastoma cells
The first total synthesis for the novel fatty acid (±)-2-methoxy-6-icosynoic acid was accomplished in seven steps and in a 14% overall yield starting from 2-(4-bromobutoxy)- tetrahydro-2H-pyran. The title compound displayed an EC(50) = 23 ± 1 µM against the human SHSY5Y neuroblastoma cell line and a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4110677/ https://ncbi.nlm.nih.gov/pubmed/23648411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chemphyslip.2013.04.004 |
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