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Protein Degradation and Quality Control in Cells from Laforin and Malin Knockout Mice

Lafora disease is a progressive myoclonus epilepsy caused by mutations in the EPM2A or EPM2B genes that encode a glycogen phosphatase, laforin, and an E3 ubiquitin ligase, malin, respectively. Lafora disease is characterized by accumulation of insoluble, poorly branched, hyperphosphorylated glycogen...

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書誌詳細
主要な著者: Garyali, Punitee, Segvich, Dyann M., DePaoli-Roach, Anna A., Roach, Peter J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110273/
https://ncbi.nlm.nih.gov/pubmed/24914213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580167
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