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Synergistic Signaling of Tumor Cell Invasiveness by Hepatocyte Growth Factor and Hypoxia
Hepatocyte growth factor (HGF) signaling promotes tumor invasiveness in renal cell carcinoma (RCC) and other cancers. In clear cell RCC, VHL loss generates pseudohypoxia that exacerbates HGF-driven invasion through β-catenin deregulation. Hypoxia also enhances HGF-driven invasiveness by papillary RC...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4110257/ https://ncbi.nlm.nih.gov/pubmed/24914205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580597 |
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