Integrin α6β4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF)

Integrin α6β4 is up-regulated in pancreatic adenocarcinomas where it contributes to carcinoma cell invasion by altering the transcriptome. In this study, we found that integrin α6β4 up-regulates several genes in the epidermal growth factor receptor (EGFR) pathway, including amphiregulin (AREG), epir...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Carpenter, Brittany L., Chen, Min, Knifley, Teresa, Davis, Kelley A., Harrison, Susan M. W., Stewart, Rachel L., O'Connor, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646402/
https://ncbi.nlm.nih.gov/pubmed/26381405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686873
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