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Huntingtin Protein is Essential for Mitochondrial Metabolism, Bioenergetics and Structure in Murine Embryonic Stem Cells

Mutations in the Huntington locus (htt) have devastating consequences. Gain-of-poly-Q repeats in Htt protein causes Huntington's disease (HD), while htt(-/-) mutants display early embryonic lethality. Despite its importance, the function of Htt remains elusive. To address this, we compared more...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ismailoglu, Ismail, Chen, Qiuying, Popowski, Melissa, Yang, Lili, Gross, Steven S., Brivanlou, Ali H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109978/
https://ncbi.nlm.nih.gov/pubmed/24780625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.04.005
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