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A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human embryonic stem cells (hESCs) can generate the three germ layers in culture, however, differentiation is typically heterogeneous and spatially disordered. Here we show that geometric confinement is sufficient to tr...
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| Publicado no: | Nat Methods |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4341966/ https://ncbi.nlm.nih.gov/pubmed/24973948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3016 |
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