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Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor

The epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, migration, and differentiation, and aberrant EGFR signaling is implicated in a variety of cancers. EGFR signaling is triggered by extracellular ligand binding, which promotes EGFR dimerization and activati...

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Библиографические подробности
Главные авторы: Arkhipov, Anton, Shan, Yibing, Kim, Eric T., Shaw, David E.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109842/
https://ncbi.nlm.nih.gov/pubmed/25058506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003742
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