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Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor
The epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, migration, and differentiation, and aberrant EGFR signaling is implicated in a variety of cancers. EGFR signaling is triggered by extracellular ligand binding, which promotes EGFR dimerization and activati...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109842/ https://ncbi.nlm.nih.gov/pubmed/25058506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003742 |
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