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Structural basis for negative cooperativity in growth factor binding to an EGF receptor

Transmembrane signaling by the epidermal growth factor receptor (EGFR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kinase domain. Crystallographic studies have shown how ligand binding induces dimerization of the EGFR extracellular region, but cannot...

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Autori principali: Alvarado, Diego, Klein, Daryl E., Lemmon, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925043/
https://ncbi.nlm.nih.gov/pubmed/20723758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.015
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