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Structural basis for negative cooperativity in growth factor binding to an EGF receptor
Transmembrane signaling by the epidermal growth factor receptor (EGFR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kinase domain. Crystallographic studies have shown how ligand binding induces dimerization of the EGFR extracellular region, but cannot...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925043/ https://ncbi.nlm.nih.gov/pubmed/20723758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.015 |
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