Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the relev...

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Bibliografiske detaljer
Main Authors: Parish, Ian A., Marshall, Heather D., Staron, Matthew M., Lang, Philipp A., Brüstle, Anne, Chen, Jonathan H., Cui, Weiguo, Tsui, Yao-Chen, Perry, Curtis, Laidlaw, Brian J., Ohashi, Pamela S., Weaver, Casey T., Kaech, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109559/
https://ncbi.nlm.nih.gov/pubmed/25003188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66108
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