Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties

During acute infections, a small population of effector CD8 T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional repressor Blimp-1 enhances the formation of terminally differentiated CD8 T cells during LCMV infection, and Blimp-1...

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Detalhes bibliográficos
Main Authors: Rutishauser, Rachel L., Martins, Gislâine A., Kalachikov, Sergey, Chandele, Anmol, Parish, Ian A., Meffre, Eric, Jacob, Joshy, Calame, Kathryn, Kaech, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783637/
https://ncbi.nlm.nih.gov/pubmed/19664941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.014
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