S100/calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a RAGE dependent manner

OBJECTIVE: S100A12 and fibroblast growth factor 23 (FGF23) are biomarkers of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD. APPROACH AND RESUL...

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Bibliographic Details
Main Authors: Yan, Ling, Mathew, Liby, Chellan, Bijoy, Gardner, Brandon, Earley, Judy, Puri, Tipu S., Hofmann Bowman, Marion A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108264/
https://ncbi.nlm.nih.gov/pubmed/24855059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303508
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