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Substrate Activity Screening for Kinases: Discovery of Small Molecule Substrate-Competitive c-Src Inhibitors()
Substrate-competitive kinase inhibitors represent a promising class of kinase inhibitors, however, there is no methodology to selectively identify this type of inhibitor. Herein, we report the application of substrate activity screening to tyrosine kinases. Using this methodology, we have discovered...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108202/ https://ncbi.nlm.nih.gov/pubmed/24797781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201311096 |
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