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Irreversible inhibitors of c-Src kinase that target a non-conserved cysteine
We have developed the first irreversible inhibitors of wild-type c-Src kinase. We demonstrate that our irreversible inhibitors display improved potency and selectivity relative to their reversible counterparts. Our strategy involves modifying a promiscuous kinase inhibitor with an electrophile to ge...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500393/ https://ncbi.nlm.nih.gov/pubmed/22928736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300337u |
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