Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci

BACKGROUND: A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome t...

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Detalhes bibliográficos
Main Authors: Smeets, Daniel, Markaki, Yolanda, Schmid, Volker J, Kraus, Felix, Tattermusch, Anna, Cerase, Andrea, Sterr, Michael, Fiedler, Susanne, Demmerle, Justin, Popken, Jens, Leonhardt, Heinrich, Brockdorff, Neil, Cremer, Thomas, Schermelleh, Lothar, Cremer, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108088/
https://ncbi.nlm.nih.gov/pubmed/25057298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-7-8
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