A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

BACKGROUND: Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growing reason to believe that tumor-specific alteration of redox control of metabol...

詳細記述

保存先:
書誌詳細
主要な著者: Stuart, Shawn D, Schauble, Alexandra, Gupta, Sunita, Kennedy, Adam D, Keppler, Brian R, Bingham, Paul M, Zachar, Zuzana
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108059/
https://ncbi.nlm.nih.gov/pubmed/24612826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-2-4
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