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α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor
α-Ketoglutarate dehydrogenase (KGDH), a key regulatory enzyme within the Krebs cycle, is sensitive to mitochondrial redox status. Treatment of mitochondria with H(2)O(2) results in reversible inhibition of KGDH due to glutathionylation of the cofactor, lipoic acid. Upon consumption of H(2)O(2), glut...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169906/ https://ncbi.nlm.nih.gov/pubmed/21110783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2010.534163 |
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