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α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

α-Ketoglutarate dehydrogenase (KGDH), a key regulatory enzyme within the Krebs cycle, is sensitive to mitochondrial redox status. Treatment of mitochondria with H(2)O(2) results in reversible inhibition of KGDH due to glutathionylation of the cofactor, lipoic acid. Upon consumption of H(2)O(2), glut...

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Bibliografski detalji
Glavni autori: MCLAIN, AARON L., SZWEDA, PAMELA A., SZWEDA, LUKE I.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169906/
https://ncbi.nlm.nih.gov/pubmed/21110783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2010.534163
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