Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles

Patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have distinct clinical and biological features. Whereas most DS-ALL cases lack the sentinel cytogenetic lesions that guide risk assignment in childhood ALL, JAK2 mutations and CRLF2 overexpression are highly enriched. To further...

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Hauptverfasser: Loudin, Michael G., Wang, Jinhua, Leung, Hon-Chiu Eastwood, Gurusiddappa, Sivashankarappa, Meyer, Julia, Condos, Gregory, Morrison, Debra, Tsimelzon, Anna, Devidas, Meenakshi, Heerema, Nyla A., Carroll, Andrew J., Plon, Sharon E., Hunger, Stephen P., Basso, Giuseppe, Pession, Andrea, Bhojwani, Deepa, Carroll, William L., Rabin, Karen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107887/
https://ncbi.nlm.nih.gov/pubmed/21647151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.128
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