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Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice
Metabolism of nicotine to inactive cotinine by hepatic enzyme CYP2A6 is the principal pathway by which active nicotine is removed from circulation. We therefore hypothesized that inhibition of mouse CYP2A5, the orthologue of human CYP2A6, by methoxsalen (8-methoxypsoralen) should block nicotine meta...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4106981/ https://ncbi.nlm.nih.gov/pubmed/24859605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.05.006 |
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