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Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice

Metabolism of nicotine to inactive cotinine by hepatic enzyme CYP2A6 is the principal pathway by which active nicotine is removed from circulation. We therefore hypothesized that inhibition of mouse CYP2A5, the orthologue of human CYP2A6, by methoxsalen (8-methoxypsoralen) should block nicotine meta...

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Hlavní autoři: Bagdas, Deniz, Muldoon, Pretal P., Zhu, Andy Z.X., Tyndale, Rachel F., Damaj, M. Imad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106981/
https://ncbi.nlm.nih.gov/pubmed/24859605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.05.006
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