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Desmosterol in brain is elevated because DHCR24 needs REST for robust expression but REST is poorly expressed
Cholesterol synthesis in fetal brain is inhibited because activity of DHCR24 (24-dehydrocholesterol reductase) is insufficient causing concentrations of the precursor desmosterol to increase temporarily to 15-25% of total sterols at birth. We demonstrate that failure of DHCR24 to be adequately upreg...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4106903/ https://ncbi.nlm.nih.gov/pubmed/24861183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000362363 |
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