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Codon-by-Codon Modulation of Translational Speed and Accuracy Via mRNA Folding

Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage. However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff. Here we provide genomic evidence in budding yeast and mouse embryonic stem cells that the efficiency–accurac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Jian-Rong, Chen, Xiaoshu, Zhang, Jianzhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106722/
https://ncbi.nlm.nih.gov/pubmed/25051069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001910
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