T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

On the lupus-prone MRL-lpr/lpr (MRL-lpr) background AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles. Using multiple strategies to impair T cells, we found that such AM14 B cell activation did not require T cel...

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Hauptverfasser: Herlands, Robin A., Christensen, Sean R., Sweet, Rebecca A., Hershberg, Uri, Shlomchik, Mark J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106705/
https://ncbi.nlm.nih.gov/pubmed/18691914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.06.009
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