Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.

DNA topoisomerase I (top1) is a ubiquitous nuclear enzyme. It is specifically inhibited by camptothecin, a natural product derived from the bark of the tree Camptotheca acuminata. Camptothecin and several of its derivatives are presently in clinical trial and exhibit remarkable anticancer activity....

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pommier, Y, Kohlhagen, G, Kohn, K W, Leteurtre, F, Wani, M C, Wall, M E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8861
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!