Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.

DNA topoisomerase I (top1) is a ubiquitous nuclear enzyme. It is specifically inhibited by camptothecin, a natural product derived from the bark of the tree Camptotheca acuminata. Camptothecin and several of its derivatives are presently in clinical trial and exhibit remarkable anticancer activity....

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Pommier, Y, Kohlhagen, G, Kohn, K W, Leteurtre, F, Wani, M C, Wall, M E
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8861
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