Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription

Although soluble species of the amyloid-β peptide Aβ42 correlate with disease symptoms in Alzheimer disease, little is known about the biological activities of amyloid-β (Aβ). Here, we show that Aβ peptides varying in lengths from 38 to 43 amino acids are internalized by cultured neuroblastoma cells...

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Detalhes bibliográficos
Main Authors: Barucker, Christian, Harmeier, Anja, Weiske, Joerg, Fauler, Beatrix, Albring, Kai Frederik, Prokop, Stefan, Hildebrand, Peter, Lurz, Rudi, Heppner, Frank L., Huber, Otmar, Multhaup, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106333/
https://ncbi.nlm.nih.gov/pubmed/24878959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564690
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