Mesotrypsin and Caspase-14 Participate in Prosaposin Processing: POTENTIAL RELEVANCE TO EPIDERMAL PERMEABILITY BARRIER FORMATION

A proteomics-based search for molecules interacting with caspase-14 identified prosaposin and epidermal mesotrypsin as candidates. Prosaposin is a precursor of four sphingolipid activator proteins (saposins A–D) that are essential for lysosomal hydrolysis of sphingolipids. Thus, we hypothesized that...

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Detalhes bibliográficos
Main Authors: Yamamoto-Tanaka, Mami, Motoyama, Akira, Miyai, Masashi, Matsunaga, Yukiko, Matsuda, Junko, Tsuboi, Ryoji, Hibino, Toshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106320/
https://ncbi.nlm.nih.gov/pubmed/24872419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543421
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